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NE reuptake inhibition was assessed as antagonism of tetrabenazine-induced ptosis in mice, and paroxetine showed NE reuptake-inhibiting activity at doses close to those that produced 5-HT reuptake inhibition ().

Escitalopram has met this criterion with seven studies, but neither sertraline nor paroxetine was able to rely on a single study and therefore cannot be considered superior ().

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Activity of specific monoaminergic pathways in this context are viewed as “upstream” events that influence “downstream” events, such as changes in gene expression and protein synthesis, which ultimately cause depression and modulate responses to antidepressants.

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Both the low- and high-risk groups regularly craved their medication, which was linked to urge, preoccupation, and mood.

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Doshi D, Borison R "Association of transient SIADH with sertraline.

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Bupropion (Wellbutrin, Aplenzin, Forfivo XL) falls into this category.

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In three men and two women treated with or sertraline (SSRI drugs closely related to paroxetine) for depression who experienced sexual dysfunction, addition of Ginkgo biloba extract (GBE) in the amount of 240 mg per day effectively reversed the sexual dysfunction.

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At typical doses, these medications block the reuptake of serotonin, a chemical in the brain thought to be associated with depression and other disorders.

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Conversely, the exclusion of children and teens with major depression and pervasive developmental disorders may have limited the generalizability of the results to these populations.

This mental health condition is classified as an anxiety disorder wherein the patient is occupied with intrusive thoughts (obsession) that may generate worry, anxiety, and fear and feels a strong urge to engage in certain repetitive behaviors (compulsion) in order to reduce such unpleasant feelings.

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Polusney et al suggests that combat-related PTSD is strongly associated with postconcussive symptoms and psychosocial outcomes one year after return from Iraq; however, little evidence of a long-term negative impact due to concussion and mild traumatic brain injury after accounting for PTSD.

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And when referring to Prozac and other SSRI's and sufficient historical context please remember, this is not a book about SSRI's we are discussing, but an article about sertraline.

It is not known whether, and if so in what amount, sertraline or its metabolites are excreted in human milk.

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